ParkinsonCanadaV1, Main, Exploration, bibRecord, 001070

Extrasynaptic GABAA Receptors in the Brainstem and Spinal Cord: Structure and Function

Identifieur interne : 001070 ( Main/Exploration ); précédent : 001069; suivant : 001071

Extrasynaptic GABAA Receptors in the Brainstem and Spinal Cord: Structure and Function

Auteurs : Rodolfo Delgado-Lezama [Mexique] ; Emanuel Loeza-Alcocer [Mexique] ; Carmen Andres [Mexique] ; Justo Aguilar [Mexique] ; Pierre A. Guertin [Canada] ; Ricardo Felix [Mexique]

Source :

Current pharmaceutical design : (Print) [ 1381-6128 ] ; 2013.

RBID : Pascal:14-0057759

Descripteurs français

Pascal (Inist)
- Récepteur gabaergique A, Tronc cérébral, Moelle épinière, Fonction structure, GABA, Primaire, Fibre, Régime alimentaire, Nutrition, Article synthèse.
Wicri :
- topic : Nutrition.

English descriptors

KwdEn :
- Brain stem, Diet, Fiber, GABA, Gabaergic receptor A, Nutrition, Primary, Review, Spinal cord, Structure function.

Abstract

γ-aminobutyric acid (GABA) plays many of its key roles in embryonic development and functioning of the central nervous system (CNS) by acting on ligand gated chloride-permeable channels known as GABA_A receptors (GABA_AR). Classically, GABA_AR-mediated synaptic communication is tailored to allow rapid and precise transmission of information to synchronize the activity of large populations of cells to generate and maintain neuronal networks oscillations. An alternative type of inhibition mediated by GABA_A receptors, initially described about 25 years ago, is characterized by a tonic activation of receptors that react to ambient extracellular GABA. The receptors that mediate this action are wide-spread throughout the nerve cells but are located distant from the sites of GABA release, and therefore they have been called extrasynaptic GABA_A receptors. The molecular nature of the extrasynaptic GABA_A receptors and the tonic inhibitory current they generate have been characterized in many brain structures, and due to its relevance in controlling neuron excitability they have become attractive pharmacological targets for a variety of neurological disorders such as schizophrenia, epilepsy and Parkinson disease. In the spinal cord, early studies have implicated these receptors in anesthesia, chronic pain, motor control, and locomotion. This review highlights past and present developments in the field of extrasynaptic GABA_A receptors and emphasizes their subunit containing distribution and physiological role in the spinal cord.

Affiliations:

Canada, Mexique

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000038
to stream PascalFrancis, to step Curation: 000B80
to stream PascalFrancis, to step Checkpoint: 000080
to stream Main, to step Merge: 001087
to stream Main, to step Curation: 001070

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Extrasynaptic GABA<sub>A </sub>
Receptors in the Brainstem and Spinal Cord: Structure and Function</title>
<author><name sortKey="Delgado Lezama, Rodolfo" sort="Delgado Lezama, Rodolfo" uniqKey="Delgado Lezama R" first="Rodolfo" last="Delgado-Lezama">Rodolfo Delgado-Lezama</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loeza Alcocer, Emanuel" sort="Loeza Alcocer, Emanuel" uniqKey="Loeza Alcocer E" first="Emanuel" last="Loeza-Alcocer">Emanuel Loeza-Alcocer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andres, Carmen" sort="Andres, Carmen" uniqKey="Andres C" first="Carmen" last="Andres">Carmen Andres</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aguilar, Justo" sort="Aguilar, Justo" uniqKey="Aguilar J" first="Justo" last="Aguilar">Justo Aguilar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guertin, Pierre A" sort="Guertin, Pierre A" uniqKey="Guertin P" first="Pierre A." last="Guertin">Pierre A. Guertin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry and Neurosciences, Laval University</s1>
<s2>Quebec City</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Felix, Ricardo" sort="Felix, Ricardo" uniqKey="Felix R" first="Ricardo" last="Felix">Ricardo Felix</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cell Biology, Cinvestav-IPN</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0057759</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 14-0057759 INIST</idno>
<idno type="RBID">Pascal:14-0057759</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000038</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B80</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000080</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000080</idno>
<idno type="wicri:Area/Main/Merge">001087</idno>
<idno type="wicri:Area/Main/Curation">001070</idno>
<idno type="wicri:Area/Main/Exploration">001070</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Extrasynaptic GABA<sub>A </sub>
Receptors in the Brainstem and Spinal Cord: Structure and Function</title>
<author><name sortKey="Delgado Lezama, Rodolfo" sort="Delgado Lezama, Rodolfo" uniqKey="Delgado Lezama R" first="Rodolfo" last="Delgado-Lezama">Rodolfo Delgado-Lezama</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loeza Alcocer, Emanuel" sort="Loeza Alcocer, Emanuel" uniqKey="Loeza Alcocer E" first="Emanuel" last="Loeza-Alcocer">Emanuel Loeza-Alcocer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andres, Carmen" sort="Andres, Carmen" uniqKey="Andres C" first="Carmen" last="Andres">Carmen Andres</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aguilar, Justo" sort="Aguilar, Justo" uniqKey="Aguilar J" first="Justo" last="Aguilar">Justo Aguilar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN)</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guertin, Pierre A" sort="Guertin, Pierre A" uniqKey="Guertin P" first="Pierre A." last="Guertin">Pierre A. Guertin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry and Neurosciences, Laval University</s1>
<s2>Quebec City</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Felix, Ricardo" sort="Felix, Ricardo" uniqKey="Felix R" first="Ricardo" last="Felix">Ricardo Felix</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cell Biology, Cinvestav-IPN</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Current pharmaceutical design : (Print)</title>
<title level="j" type="abbreviated">Curr. pharm. des. : (Print)</title>
<idno type="ISSN">1381-6128</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Current pharmaceutical design : (Print)</title>
<title level="j" type="abbreviated">Curr. pharm. des. : (Print)</title>
<idno type="ISSN">1381-6128</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain stem</term>
<term>Diet</term>
<term>Fiber</term>
<term>GABA</term>
<term>Gabaergic receptor A</term>
<term>Nutrition</term>
<term>Primary</term>
<term>Review</term>
<term>Spinal cord</term>
<term>Structure function</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Récepteur gabaergique A</term>
<term>Tronc cérébral</term>
<term>Moelle épinière</term>
<term>Fonction structure</term>
<term>GABA</term>
<term>Primaire</term>
<term>Fibre</term>
<term>Régime alimentaire</term>
<term>Nutrition</term>
<term>Article synthèse</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Nutrition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">γ-aminobutyric acid (GABA) plays many of its key roles in embryonic development and functioning of the central nervous system (CNS) by acting on ligand gated chloride-permeable channels known as GABA<sub>A</sub>
 receptors (GABA<sub>A</sub>
R). Classically, GABA<sub>A</sub>
R-mediated synaptic communication is tailored to allow rapid and precise transmission of information to synchronize the activity of large populations of cells to generate and maintain neuronal networks oscillations. An alternative type of inhibition mediated by GABA<sub>A</sub>
 receptors, initially described about 25 years ago, is characterized by a tonic activation of receptors that react to ambient extracellular GABA. The receptors that mediate this action are wide-spread throughout the nerve cells but are located distant from the sites of GABA release, and therefore they have been called extrasynaptic GABA<sub>A</sub>
 receptors. The molecular nature of the extrasynaptic GABA<sub>A</sub>
 receptors and the tonic inhibitory current they generate have been characterized in many brain structures, and due to its relevance in controlling neuron excitability they have become attractive pharmacological targets for a variety of neurological disorders such as schizophrenia, epilepsy and Parkinson disease. In the spinal cord, early studies have implicated these receptors in anesthesia, chronic pain, motor control, and locomotion. This review highlights past and present developments in the field of extrasynaptic GABA<sub>A</sub>
 receptors and emphasizes their subunit containing distribution and physiological role in the spinal cord.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Mexique</li>
</country>
</list>
<tree><country name="Mexique"><noRegion><name sortKey="Delgado Lezama, Rodolfo" sort="Delgado Lezama, Rodolfo" uniqKey="Delgado Lezama R" first="Rodolfo" last="Delgado-Lezama">Rodolfo Delgado-Lezama</name>
</noRegion>
<name sortKey="Aguilar, Justo" sort="Aguilar, Justo" uniqKey="Aguilar J" first="Justo" last="Aguilar">Justo Aguilar</name>
<name sortKey="Andres, Carmen" sort="Andres, Carmen" uniqKey="Andres C" first="Carmen" last="Andres">Carmen Andres</name>
<name sortKey="Felix, Ricardo" sort="Felix, Ricardo" uniqKey="Felix R" first="Ricardo" last="Felix">Ricardo Felix</name>
<name sortKey="Loeza Alcocer, Emanuel" sort="Loeza Alcocer, Emanuel" uniqKey="Loeza Alcocer E" first="Emanuel" last="Loeza-Alcocer">Emanuel Loeza-Alcocer</name>
</country>
<country name="Canada"><noRegion><name sortKey="Guertin, Pierre A" sort="Guertin, Pierre A" uniqKey="Guertin P" first="Pierre A." last="Guertin">Pierre A. Guertin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001070 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001070 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:14-0057759
   |texte=   Extrasynaptic GABAA Receptors in the Brainstem and Spinal Cord: Structure and Function
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Extrasynaptic GABAA Receptors in the Brainstem and Spinal Cord: Structure and Function

Extrasynaptic GABAA Receptors in the Brainstem and Spinal Cord: Structure and Function

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri